Clint Eastwood's day would have been made. I'll tell you... it couldn't get much better than this.
We've known for some time that grape seed extract can wreak some major havoc with cancer in laboratory tests, but perhaps this news is the biggest of all.
In a new in vitro experiment, grape seed extract caused human leukemia cells to commit cell suicide (a process known as apoptosis). In normal English, what this means that in LAB experiments (not on live humans - just their cancerous cells), scientists "fed" grape seed extract to cancerous cells.
And, like feeding me brussels sprouts, the cells didn't care much for the grape seed extract. As a matter of fact, it made the leukemia cells commit suicide. (No, brussels sprouts won't kill you... I simply don't like them).
In past studies, grape seed extract has had similar results against other cancer cell lines including skin, breast, colon, lung, stomach and prostate cancers. However, until now, the extract had not been tested with leukemia.
This gets better, too... Nobody has ever known HOW the grape seed extract fights these cancers. So, this time, researches took aim at understanding the exact effects grape seed extract has on leukemia cells.
The scientists, who report their findings in Clinical Cancer Research, treated human leukemia cells with varying doses of grape seed extract. Their findings indicated that within 24 hours, 76 percent of leukemia cells had died after being exposed to the higher dose of the extract. The extract did not affect normal cells.
The researchers also investigated the cell signaling pathway associated with use of grape seed extract that led the cancer cells to commit suicide. They found that the extract activates JNK, a protein that regulates the apoptosis pathway (the road to suicide).
To confirm this finding, they used an agent to inhibit JNK and found that the grape seed was then ineffective. Additionally, they silenced the JNK gene (made it inactive) and found that this too canceled out grape seed extract’s ability to cause cell suicide in the leukemia cells, confirming that the extract does indeed work by activating JNK.
"These results could have implications for the incorporation of agents such as grape seed extract into prevention or treatment of hematological malignancies and possibly other cancers," said the study"s lead author, Xianglin Shi, Ph.D., in a press release issued by the American Association for Cancer Research. "What everyone seeks is an agent that has an effect on cancer cells but leaves normal cells alone, and this shows that grape seed extract fits into this category."
Translation of the above quote: "Hey... maybe we can use grape seed to prevent leukemia and other cancers."
After calling for more studies to confirm the results of the findings, Shi said, “"This is a natural compound that appears to have relatively important properties.”
Please don't use this as an excuse to drink more wine. It's the EXTRACT from the grape seed, highly condensed, that does the trick.
Maybe THAT'S why Moxxor decided to put an extract from the New Zealand Sauvingnon grape seed into their product to supplement the omega-3 in the green lipped mussel... VERY clever fellows, those fishermen who started the MOXXOR company.
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